Nephritis – Grade 2

Management escalation pathway

• Withhold ICPI
• Hydration and review creatinine in 48-72h; if not improving, discuss with nephrologist the need for biopsy and if attributed to irAE, initiate steroids (oral prednisolone 1mg/kg)
• When returning to Grade 1, or baseline: restart ICPI might be discussed upon corticoid stop

Assessment and Investigations

• Renal ultrasound +/- doppler to exclude obstructions or a clot
• If proteinuria: 24h collection or UPCR
• Advise patient to notify if oliguric