Muscle pathology

Polymyalgia rheumatica

Typically inflammatory girdle (shoulder and pelvic) stiffness and pain


Muscle weakness Muscle pain
CK elevation

Alarm symptoms:

  • diaphragm paralysis
  • Myocarditis
  • Swallowing troubles
  • Diplopia
  • Dyspnea due to respiratory muscle involvement
More information

Myastenia gravis

Fluctuating muscle weakness (proximal limb, trunk, ocular, e.g. ptosis/diplopia or bulbar) respiratory muscles may also be involved


Muscle weakness is induced and aggravated by exercise

In collaboration with

Rhumato-onco taskforce KBVR/SRBR (Yves Piette, Ellen Delanghe) Gauthier Remiche, ULB Erasme
Olivier Lambotte, AP-HP, Hôpital Bicêtre, Service de Médecine
Interne et Immunologie Clinique, Paris, France,
Dimitri Psimaras, Practicien Hospitalier
Département de Neurologie Mazarin, GHPS, Paris, France



ACPA: Anti Citrullinated Antibody
ANF: Anti Nuclear Factor
C3/C4: Complement Factor 3 or 4
CK: Creatine Kinase
CK MB: Creatine Kinase Muscle
ECG: ElectroCardioGram
EMG: ElectroMyoGram
ICPi: Immune Checkpoint Blockade Inhibition
MRI: Magnetic Resonance Imaging
PD: Per Day
PO: Per Os
Pro-BNP: Pro-Brain Natriuretic Peptide
RF: Rheuma Factor
ULN: Upper Limit of Normal