Skin toxicity – Grade 2-4 – High risk

Assessment and investigations

  • Perform biopsy
  • Perform blood analysis

Management escalation pathway

  • Hospitalize in ICU/burn unit
  • Apply electrolyte and fluid control
  • Apply nutritional control initiated antibiotic therapy as indicated
  • Apply general burn unit measures (e.g. sterile handling, antiseptic solution, repeated cultures, pain management …)
  • Withhold ICPI and consider other causes (treatment related, paraneoplastic, …)
  • Instore systemic immunosuppression (corticoids and beyond)


BSA: Body Surface Area
ADL: Activities of Daily Living
BW: Body Weight
ICU: Intensive Care Unit