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Belgian Multidisciplinary Immunotoxicity Board (BITOX)
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Peripheral neurological toxicity
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Uncomplicated Peripheral neuropathy
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Uncomplicated Peripheral neuropathy – Severe
Overview
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Uncomplicated Peripheral neuropathy – Severe
Mild
Moderate
Severe
Management escalation pathway
Withhold ICPI and admit patient Initiate (methyl) prednisolone 2mg/kg i.v.
Involve neurologist in care
Respiratory function should be checked 6 x pd
Daily or more frequent neurological review according to severity
Multidisciplinary team involvement:
Physiotherapy, occupational therapy and speech therapy as appropriate, opthalmology review for ocular/cranial nerve issues
Orthopedic devices (e.g. for foot drop) should be considered
Assessment and Investigations
MRI brain/spine advised
EMG
Lumbar puncture
Consider pulmonary function or diafragmatic function tests
Neurological consult
Abbreviations
Abbrevations
CMV:
Cytomegalovirus
CIDP:
Chronic Inflammatory Demyelinating Polyneuropathy
GBS:
Guillain Barré Syndrome
PJP:
Pneumocystis Jirovei Pneumopathy