Muscle pathology

Polymyalgia rheumatica

  • Typically inflammatory girdle (shoulder and pelvic) stiffness and pain


  • Muscle weakness
  • Muscle pain
  • CK elevationv

Alarm symptoms:

  • Diaphragm paralysis
  • Concomitant myocarditis
  • Swallowing troubles
  • Diplopia
  • Dyspnea due to respiratory muscle involvement

Myastenia gravis

  • Fluctuating muscle weakness (proximal limb, trunk, ocular, e.g. ptosis/diplopia or bulbar)
  • Respiratory muscles may also be involved

Muscle weakness is induced and aggravated by exercise



ACPA: Anti Citrullinated Antibody
ANF: Anti Nuclear Factor
C3/C4: Complement Factor 3 or 4
CK: Creatine Kinase
CK MB: Creatine Kinase Muscle
ECG: ElectroCardioGram
EMG: ElectroMyoGram
ICPi: Immune Checkpoint Blockade Inhibition
MRI: Magnetic Resonance Imaging
PD: Per Day
PO: Per Os
Pro-BNP: Pro-Brain Natriuretic Peptide
RF: Rheuma Factor
ULN: Upper Limit of Normal

In collaboration with

Rhumato-onco taskforce KBVR/SRBR (Yves Piette, Ellen Delanghe)

Gauthier Remiche, ULB Erasme

Olivier Lambotte, AP-HP, Hôpital Bicêtre, Service de Médecine Interne et Immunologie Clinique, Paris, France

Dimitri Psimaras, Praticien Hospitalier, Département de Neurologie Mazarin, GHPS, Paris, France

Note: This is not a diagnosis/management tool for patients: patients should always consult their treating specialist