- Fatigue, hepatitis, diarrhea and hypothyroidism are AE that could be induced by both TKI and ICPI
- Grade II-III-IV toxicity: stop Axitinib: symptoms should regress within 72 hours
- Restart Axitinib in dose and timing according to usual recommendations (link to be added)
Warning signs for immune-related Adverse Events: these should be treated as such (overview immunomanager)
- Rapid deterioration of one single AE
- Fever
- >1 suspected immune-related AE
- High CRP (which cannot be explained by other causes)
- Symptoms that do not regress within 72h of stop of Axitinib
- Note: This is not a diagnosis/management tool for patients: patients should always consult their treating specialist