Silent Hypophysitis

Assessment and Investigations

Hypophysitis Unlikely
  • 8 am or random cortisol >160 µg/L
Possible
  • 8 am cortisol 70-160 µg/L
  • Or random cortisol 30-160 µg/L
Likely
  • 8 am cortisol <70 µg/L
  • Or random cortisol <30 µg/L

Management

  • Await hormonal assessment (<24h)
  • Start physiological substitution with hydrocortisone 10-5-5mg if hypophysitis possible or likely
  • Continue ICPI once adequately substituted
Abbreviations

Abbrevations

ICPi: Immune Checkpoint Blockade Inhibition