Did the diarrhea stop within 72h (1)

Yes, it stopped within 72 hours

Initiate oral methylprednisolone (medrol 32 mg comp) at a dose of 2x 32 mg per day.

Taper steroids every 5 days (provide taper plan on paper to the patient)

Control blood tests weekly until normal or return to baseline
In case or recurrence, treat according to medium risk management guidelines

Resume ICPi >1 week after stopping steroid therapy and in the absence of diarrhea/colitis recurrence

No, it dit not stop within 72 hours

Administer infliximab 5 mg/kg + methylprednisolone 40mg iv BID (after discussion with gastroenterologist)



H: Hematology
C: Chemistry
ICPi: Immune Checkpoint Blockade Inhibition
Hb: Hemoglobin
CRP: C Reactive Protein
BP: Blood Pressure