Hyperthyroidism

Low TSH and increased fT4 and/or fT3

Hyperthyroidism related to ICPI is generally transient and followed by hypothyroidism where adequate substitution is indicated.
Therefore, antithyroid drugs are not required.

 

Asymptomatic

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Symptomatic

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Severe

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Abbreviations

Abbrevations

ICPi: Immune Checkpoint Blockade Inhibition
TSH: Thyroid-Stimulating Hormone
FT4: Free Thyroxin
TSI: Thyroid Stimulating Immunoglobulins